Abeloff's Clinical Oncology

 Our understanding and treatment of cancer have always relied heavily on parallel developments in biological research. Molecular biology provides the basic tools to study genes involved with cancer growth patterns and tumor suppression. An advanced understanding of the molecular processes governing cell growth and differentiation has revolutionized the diagnosis and prognosis of malignant disorders. basic principles of molecular biology to emerging perspectives on  the origin and progression of cancer and explains newly developed  laboratory techniques, including whole genome  analysis, expression profling, and refned genetic manipulation in animal models, thus providing the conceptual and technical background necessary to grasp the central principles and new methods of current cancer research Since the  last edition of this book was  published, advances in our understanding of the basic mechanisms  of cancer have continued to inform and refne clinical approaches to prevention and therapy. New prognostic and predictive markers derived from molecular biology can now pinpoint specifc genetic changes in particular tumors or detect occult malignant cells  in normal tissues, leading  to improved technologies for tumor screening and early detection.  Diagnostic approaches have expanded from morphologic criteria and single gene analysis to whole genome technologies imported from other biological disciplines. This book contains the following  materials in the introductory chapter.

• DETECTING CANCER MUTATION
• GENERATING DIVERSITY WITH ALTERNATE SPLICING
• THE GENOMICS OF CANCER
• BUILDING GENE LIBRARIES
• LOSING CONTROL OF THE GENOME
• EPIGENETICS AND CANCER
• PROFILING TUMORS
• THE CANCER PROTEOME
• MODELING CANCER IN VIVO
• TRANSGENIC MODELS OF CANCER
• CONDITIONAL CONTROL OF
• ONCOGENE ACTIVATION
• MODELS OF RECESSIVE GENE MUTATIONS IN CANCER

OTHER CONTENTS (CHAPTERS):

1. Intracellular Signaling
2. The Cellular Microenvironment and Metastases
3. Control of the Cell Cycle
4. Pathophysiology of Cancer Cell Death
5. Cancer Immunolog
6. Stem Cells, Cell Differentiation, and Cancer
7. Vascular and Interstitial Biology of Tumors
8.  B. GENESIS OF CANCER: Environmental Factors
9.  DNA Damage Response Pathways and Cancer
10.  Cutaneous T-Cell Lymphoma and Cutaneous B-Cell Lymphoma

Abeloff's Clinical Oncology book contains 2817 pages and 107 chapters. Whihc will help to to understand Clinical Oncology from a to z.

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