Pathology of Malignant Mesothelioma

Recent decades have seen substantially increased worldwide incidence and mortality rates for mesothelioma. Studies in many countries have confirmed its association with asbestos exposure. Nonetheless, important scientific and public health questions still need answers.

Pathology of Malignant Mesothelioma contents:


1. Epidemiology of Mesothelioma
2. Molecular Biology
3. Serosal Anatomy and Anatomic Distribution of Mesothelioma
4. Clinical Aspects of Mesothelioma
5. Management of Malignant Serosal Effusions
6. Pathologic Diagnosis and Classification of Mesothelioma
7. Macroscopic Features of Mesotheliomas
8. Classification and Histologic Features of Mesothelioma
        A. Epithelioid Mesothelioma
        B. Biphasic Mesothelioma
        C. Sarcomatoid Mesothelioma
        D. Desmoplastic Malignant Mesothelioma
        E. Lymphohistiocytoid Mesothelioma

9. Differential Diagnosis: Mesothelial  Proliferations
       A. Reactive Mesothelial Proliferations  (Epithelioid)
       B. Fibrous Pleurisy
       C. Immunohistochemical Findings in Reactive vs. Neoplastic Processes

10. Differential Diagnosis: Other Mesothelial Lesions
       A. Adenomatoid Tumors
      B. Well Differentiated Papillary Mesothelioma .
      C. Multicystic Mesothelioma

11. Differential Diagnosis: Nonmesothelial  Lesions
      A. Reactive Squamous Metaplasia
      B. Nodular Histiocytic Mesothelial Hyperplasia
     C. Endosalpingiosis
     D. Ectopic Decidua

12. Differential Diagnosis: Nonmesothelial Tumors of the Serosal Cavity: Sarcomas
     A. Synovial Sarcoma
     B. Epithelioid Hemangioendothelioma and Angiosarcoma
     C. Leiomyosarcoma
     D. Malignant Peripheral Nerve Sheath Tumor
     E. Primitive Neuroectodermal Tumor
     F. Desmoid Tumor
     G. Desmoplastic Round Cell Tumor
     H. Pleuropulmonary Blastoma
     I. Inflammatory Myofibroblastic Tumor

13. Differential Diagnosis: Other Nonmesothelial Tumors
      A. Solitary Fibrous Tumour
      B. Calcifying Fibrous Pseudotumour
     C. Leiomyomatosis Peritonealis Disseminata
      D. Thymoma/Thymic Carcinoma
     E. Melanoma
     F. Serous Carcinoma
     G. Lymphomas of the Serosal Cavities
     H. Other Lymphomas that may Involve the Pleura