This book is intended to bring solution protein chemistry to proteomic technology and to provide a different perspective from other review works. Proteomics, while a diffuse area, is an extension of classical protein chemistry largely driven by major advances in the analytical capability of mass spectrometry. The content assembles together some disparate areas into a single volume. The author has also tried to use as much classical protein chemistry literature as possible as this serves as the intellectual basis for proteomics. The author also notes that recent literature fails to recognize prior contributions and is also limited with respect to technical detail. Effective commercialization of proteomics will require more diligence in these last two areas.
1 A Brief Discussion of Proteomics — Definition – Concepts – Illusions
2 An Overview of the Chemical Modification of Proteins
3 The Application of Site-Specific Chemical Modification to
Proteomics: Chemical Proteomics
4 Sample Preparation for Proteomic Studies
5 Prefractionation
6 An Overview of Analytical Technologies Used in Proteomic Research
7 Clinical Proteomics
8 Validation Issues in Proteomics and the Transition from Research to Diagnostic Development
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